Mary’s Hospital according to the related statute. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Access to study data including de-identified data set is controlled by IRB office of Seoul St. Received: DecemAccepted: Published: June 4, 2019Ĭopyright: © 2019 Byun et al. PLoS ONE 14(6):Įditor: Radouil Tzekov, Roskamp Institute, UNITED STATES Further studies are required to reveal connections among pupillary light reflex, photophobia, and focal dystonia in benign essential blepharospasm patients with photophobia.Ĭitation: Byun Y-S, Kim S-E, Paik J-S, Yang S-W (2019) Increased pupillary constriction velocity in benign essential blepharospasm associated with photophobia. Pupillary light reflex may be related to the pathophysiology of benign essential blepharospasm with photophobia. Constriction velocity and maximum constriction velocity in the mesopic condition positively correlated with photophobia grade ( r = 0.525 and 0.617, P = 0.025 and 0.006) in the benign essential blepharospasm group. Constriction velocity and maximum constriction velocity in the mesopic condition were significantly greater in the benign essential blepharospasm group (3.26 ± 0.56 and 5.27 ± 0.90 mm/s) than in reflex (2.86 ± 0.62 and 4.59 ± 1.00 mm/s) or dry eye disease groups (2.96 ± 0.46 and 4.72 ± 0.67 mm/s). There were no differences in age, sex predominance, or dry eye disease-related parameters among the three groups, or in photophobia grade and eyelid function between benign essential blepharospasm and reflex groups. Additionally, we assessed photophobia grade, eyelid function, and dry eye disease-related parameters. Pupillary light reflex-related parameters were measured under mesopic (10 lux) and photopic illuminance (200 lux) using an infrared pupillometer. Twenty-three patients with benign essential blepharospasm, 47 with reflex blepharospasm, and 29 dry eye disease controls were included. We evaluated whether the pupillary light reflex is altered in benign essential blepharospasm patients.
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